The centrepiece on the three-day visit is the annual UK-China Summit, which takes place in London Monday and will be attended by Prime Minister David Cameron, Foreign Secretary William Hague and finance minister George Osborne.
Business deals across a range of sectors are expected to be announced at the event.
Wen will also hold talks with Deputy Prime Minister Nick Clegg and business leaders focused on green growth. The premier leaves Britain for Germany on Monday.
London sees Beijing as a key strategic partner and will be keen to use the visit to boost economic and political ties.